Crystalline Bronopol Powder

Textile Fungicide Bronopol BNPD White Crystalline Powder Good Water Solubility

It is an organic compound with the molecular formula C3H6BrNO4. It is white to light yellow crystalline powder at room temperature, odorless and tasteless, easily soluble in water, ethanol, propylene glycol, insoluble in chloroform, acetone, benzene, etc. It is mainly used as a preservative and bactericide for cosmetics, which can effectively prevent and control a variety of plant pathogenic bacteria.

Physical and chemical properties: The content of pure product is 99% (the content of aldehyde is 30%), and the appearance is white to light yellow powder or crystal. The melting point is 130°C. Vapor pressure (20°C) 1.68mPa. Solubility: water 250g/L (22°C); ethanol 500g/L, isopropanol 250g/L, propylene glycol 143g/L, glycerin 10g/L, liquid paraffin <5g/L (23~24°C). Stability: slightly hygroscopic.

Mechanism of antibacterial and antifungal effect: Bronopol has bactericidal effect through different chemical reaction mechanisms in aerobic and anaerobic atmospheres. In an aerobic atmosphere, bronopol catalyzes the oxidation of cysteine amino acids to cystine residues (Shepher et al., 1988). This mechanism is thought to act to kill microorganisms through the formation of reactive oxygen species such as superoxide or peroxide. Moreover, the formed cystine residues are attached to the cell wall, preventing the normal formation of the cell wall. The formation of reactive oxygen species and the cross-linking of cystine residues with the cell wall jointly lead to cell death. In an oxygen-free environment, the mechanism is that cells and extracellular nucleophiles attack the No. 2 carbon atom in the bronopol molecule.

The compound has good bactericidal and antibacterial effects on Gram-positive bacteria, Gram-negative bacteria, molds and yeasts, and is particularly effective on Pseudomonas aeruginosa.

The minimum inhibitory concentration (MIC) of bronopol to some microorganisms

Bronopol is mainly used as a preservative and bactericide. It is added to the processing of shampoos, balms and creams and other cosmetics. The concentration in cosmetics is 0.01%-0.02%. It can also be used in detergents and fabric treatment agents. as a bactericide. It can effectively control a variety of plant pathogenic bacteria. Cotton seeds can be treated to prevent and control cotton black arm disease and bacterial scabrous blight caused by Xanthomonas cotton, and have no phytotoxicity to cotton. It can also be used for rice bakanae disease. The recommended concentration is 800-1000mg/L. It is also used in industrial circulating water, paper pulp, coatings, plastics, cosmetics, wood, cooling water circulation systems, and sterilization, anti-mildew, anti-corrosion, and algae killing for industrial purposes.

Application: In 1919, bronopol was prepared by R.Wilkendorf, and then the British Pharmaceutical Association announced its general name Bromopol. This biocide is mainly used in industrial circulating water, paper pulp, coatings, plastics, cosmetics, wood, and cooling water circulation systems And other fields including agriculture, sterilization, anti-corrosion and anti-algae. Note: ① Due to the good stability of bronopol in acidic solutions, weakly acidic media are ideal for field applications. ② Exposure to light may make the product yellow, sensitive to iron and aluminum packaging materials, and reacts with amines and alkaline compounds. ③flammable. Produces irritating or toxic fumes (or gases) in a fire, including hydrogen bromide and nitrogen oxides.

Storage and transportation: Store in a cool, dry and ventilated place. It is strictly forbidden to mix with strong oxidants, strong alkalis, strong acids, food, mixed storage, and mixed transportation.